There are several hotels and motels seen on Lost.
- Charlie stayed at this hotel with Lily, a girl he met in "the bar" the night previous to the crash. They are both heroin addicts and it is revealed that Lily only stayed with Charlie for the drugs, and had no interest in him at all.
- Hurley set three alarms in his room the night before the crash, all of which broke (i.e., the alarm clock broke due to the plug socket burning), which made him wake up late the day after.
- As Hurley is rushing to get on the flight, he tries to get in an elevator in the hotel, but as the door opens there are too many people in there and he runs down the stairs opposite. Charlie is also in the elevator and shouts at Hurley saying, "Some of us have a bloody flight to make!"
- It is unconfirmed if this hotel is the same one at which Christian Shephard and Ana Lucia stayed.
- In the bonus features of the Season Two DVD set, the hotel is a stop on the Lost Connections.
- In the video game Lost: Via Domus, Hurley mentions that he stayed at the Hotel Persephone, which you learn whilst playing the game, is in Sydney. It is unknown if this is the same hotel as featured in the show, and if the name Hotel Persephone is in canon.
The Flightline motel, located near an airport, was seen in episode "Lockdown", during Locke's flashback, and also in "Born to Run", when it is visited by Kate. The Hale Hana Apartments on the east end of Waikiki was used as the filming location for the Flightline Motel.
- Locke's father, Anthony Cooper, rented a room here, and Locke was to meet him there after retrieving $700,000 from Cooper's safe deposit box.
- Helen followed Locke to this motel, then later said that she would not marry him.
- At one point, an Oceanic Airlines airplane flies overhead of Locke in the motel parking lot.
- It is also where Kate stops in her flashback in "Born to Run". She tells the desk clerk "I'm expecting a letter, 'hold for guest arrival,'" and gives the name Joan Hart.
- Charlie stays at the Flightline Motel in the flash-sideways timeline. ("The End")
- Jack followed his father Christian Shephard to this hotel, believing he might find a romantic rendezvous—instead he found his father at an Alcoholics Anomymous meeting in one of the hotel meeting rooms.
- The filming location for the exterior of the Lynford is actually a hospital (St. Francis Medical Center), and the same entranceway also served as a filming location for the exterior of St. Sebastian Hospital.
Seoul Gateway Hotel
- The hotel manager, Kwan-Hak Kim, interviews Jin and gives him the job of doorman at the hotel.
- Sun is introduced to Jae Lee in the hotel by Mrs. Shin, a "matchmaker".
- Jae Lee's father is the owner of the hotel. Jae Lee is expected to take a role in managing the hotel.
- Jin resigns from his job after rebelling against Mr. Kim's classism. He leaves immediately and as he walks alongside the river he bumps into Sun.
- The Royal Garden at Waikiki was used as the filming location for the Seoul Gateway. 
The Westerfield Hotel
Seen in "The Life and Death of Jeremy Bentham", this is the Los Angeles hotel where Locke stayed under the pseudonym "Jeremy Bentham". The name of the hotel is almost certainly a reference to the Westerfield Club, which featured prominently in the Adventures of Brisco County, Jr., a one-season western/comedy/science fiction television series co-created by Lost executive producer Carlton Cuse which ran for one season in 1993–1994.
- In this hotel Locke wrote his suicide note to Jack. ("316")
- Ben murdered Locke in his room. ("The Life and Death of Jeremy Bentham")
- In the newspaper clipping about Locke's death, he is stated to have died in a "downtown loft", and the article goes on to state that a doorman at "The Tower (unreadable)" checked the loft after hearing loud noises.
Other hotels and motels
- The Asiana Hotel where Jin had been employed as a waiter before working at the Seoul Gateway. ("...And Found")
- The Sage Flower Motel off Highway 29, Sioux City, Iowa—where Sawyer sent Cassidy after telling her that their lives were in danger. ("The Long Con")
- The Corn Cob Motel in Iowa where Kate dyed her hair. ("Born to Run")
- The hotel in which Jack and Sarah got married. ("Do No Harm")
- The Doral Club Motel where Kate and Kevin Callis spent the night before their wedding. ("I Do")
- The hotel where Jin confronted Jae Lee, before Lee leapt to his death. The lobby and street exterior of this hotel appeared to be different from that of the Seoul Gateway Hotel, so was either a different entrance, or a different hotel. ("The Glass Ballerina")
- The Hotel Earle where Tom likes to indulge himself in the penthouse, and where he convinced Michael to work about a freighter to save his friends. ("Meet Kevin Johnson")
- The Oasis of Palace where Ben stayed at in Tunisia after leaving the island. ("The Shape of Things to Come")
- The Century Grand Hotel where Sun stayed at in Los Angeles. ("Because You Left") ("The Little Prince")
- Rachel Blake stays in several unnamed hotels as she eludes the Hanso Foundation.
- The Rocks hotel is a metafictional Sydney location that appears in Bad Twin; Paul Artisan stays there.
- "Hotel Persephone", an episode in the video game Lost: Via Domus.
- "Kate's Motel", orchestral piece on the Season 1 soundtrack.