Kate is in a car accident in "Born to Run".
There have been many car accidents relevant to the plotline of Lost.
Kate and Ray Mullen
Kate was riding with Ray Mullen, who had turned her in to the Marshal for the reward. As the Marshal later pointed out, Kate could have escaped had she not stayed back to help rescue Ray from the vehicle. ("Tabula Rasa")
Michael was hit by a car in New York City following a heated phone conversation with Susan, in which he threatened to fly to Amsterdam to retrieve Walt. Susan paid for the ensuing hospital bill and convinced Michael to give up custody of Walt to Brian Porter, her fiance. ("Special")
"Deus Ex Machina"
Kate and Tom Brennan
"Born to Run"
Kate was involved in a car accident while driving with Tom Brennan, her childhood sweetheart, in the car. She was trying to escape the hospital after her mother alerted the security that she was there. The accident resulted in Tom's death. ("Born to Run")
Sarah Shephard and Adam Rutherford
The accident caused serious damage to Sarah's spine, which Jack miraculously fixed and ultimately led to their marriage. The accident also killed Shannon's father, which left Shannon completely broke and alone, as her step-mother, Sabrina (Boone's mother), cut her off monetarily. ("Abandoned")
Kate and the Marshal
"What Kate Did"
"Not in Portland"
Juliet's ex-husband Edmund Burke was killed by a bus as he backed into the road in Miami. He and Juliet were having a conversation about Rachel's successful experimental treatment and pregnancy. ("Not in Portland")
Claire and her mother
Claire and her mother were involved in an accident, the latter being put into a coma because of it. Immediately prior to the accident, Claire had been fighting with her mother and had said she hated her and wished her dead. ("Par Avion")
"Through the Looking Glass, Part 1"
"The Beginning of the End"
Hurley crashed his car after his car chase attempting to escape the police and the ghost of Charlie. The car jumped a curb and became airborne, and finally came to rest after crashing into the Golden Pontiac in its fourth appearance on Lost. ("The Beginning of the End")
"Meet Kevin Johnson"
Michael crashed his car while trying to commit suicide. After being driven into depression from being separated from Walt, Michael drove his car at full speed into a cargo container on a dock. ("Meet Kevin Johnson")
"The Life and Death of Jeremy Bentham"
|Locke's car was hit by several others as he sped away from Abaddon's killer. ("The Life and Death of Jeremy Bentham")|
"The Incident, Part 1"
|Nadia was fatally struck by a car while crossing the street as Jacob spoke to Sayid. ("The Incident, Part 1")|
Kate and Sawyer
|Kate crashed into James Ford's car while attempting to evade the police. Immediately after the collision, Kate jumped out of the car she was driving and ran down an alley. ("Recon")|
Desmond and Locke
"Everybody Loves Hugo"
|Locke was struck by Desmond in the parking lot of his high school, on purpose. His body flew over the car and he was visibly injured. Desmond fled the scene.|
- Clifford Widmore's mother died in a "solo car crash after a party at the country club." Cliff attributed the incident to his mother being drunk at the time, and that she was pre-occupied thinking about her husband, Arthur Widmore, who was having an affair at the time. (Bad Twin)
- Hugh McIntyre and Darla Taft were both killed in a car accident, although its accidental state was called into question by Rachel Blake. (TLE)
- Martha Toomey lost her leg in a car accident. ("Numbers")
- While not an actual collision, Rose's automobile became stuck in the snow. ("S.O.S.")
- Kate's accident ("Born to Run"), Michael's ("Special"), and Locke's ("Deus Ex Machina") were all caused by a Golden Pontiac, although Damon Lindelof confirmed that it was simply a reused prop.