De nombreux mythes de LOST semblent basé sur la science.
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Voici un extrait du Comic Con 2006 en relation avec le sujet :
Damon Lindelof: And one of the first things we talked about the very first time we came was… the sort of idea of the show dancing between the supernatural and actual science. And, as far as the island’s healing abilities, Locke’s ability to walk, and the fact that Rose was cured… and many other sort of island mysteries, we’re going to be… it’s going to get a little scientific this year, which will be fairly cool. We want to be able to bounce between those sorts of ideas, between reality and fiction. So hopefully, you will be satisfied.
Fan 12: Well, thank you very much, and from the scientific community, I appreciate it.
Damon Lindelof: And we thank the scientific community. [Crowd laughs]